Estrogens conjugated
Amnestrogen, Duavee, Estratab, Evex, Femogen, Menest, Menrium, Milprem, Pmb, Premarin, Premphase, Prempro (estrogens, conjugated) is an unknown pharmaceutical. Estrogens, conjugated was first approved as Menrium 5-2 on 1982-01-01.
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Commercial
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
114 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | — | — | 1 | — | 1 |
| Recurrence | D012008 | — | — | — | — | — | 1 | — | 1 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | — | — | 1 | — | 1 |
| Pelvic floor disorders | D059952 | — | — | — | — | — | 1 | — | 1 |
| Uterine prolapse | D014596 | EFO_1001864 | N81.4 | — | — | — | 1 | — | 1 |
| Prolapse | D011391 | — | — | — | — | — | 1 | — | 1 |
| Cystocele | D052858 | — | N81.1 | — | — | — | 1 | — | 1 |
| Hematuria | D006417 | — | R31 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Menopause | D008593 | EFO_0003922 | N95 | 2 | — | 1 | — | — | 3 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | 2 | — | 1 | 3 |
| Endometrial hyperplasia | D004714 | — | N85.0 | — | — | 1 | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Carcinoma in situ | D002278 | — | D09.9 | — | 1 | — | — | — | 1 |
| Breast carcinoma in situ | D000071960 | — | D05 | — | 1 | — | — | — | 1 |
| Ductal carcinoma breast | D018270 | — | — | — | 1 | — | — | — | 1 |
| Intraductal carcinoma noninfiltrating | D002285 | — | D05.1 | — | 1 | — | — | — | 1 |
| Postmenopause | D017698 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | — | 1 |
| Sleep | D012890 | GO_0030431 | — | 1 | — | — | — | — | 1 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | — | — | — | — | 1 |
| Metrorrhagia | D008796 | — | N92.1 | 1 | — | — | — | — | 1 |
| Vaginitis | D014627 | EFO_0005757 | N76 | 1 | — | — | — | — | 1 |
| Premature menopause | D008594 | — | E28.31 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Estrogens conjugated |
| INN | — |
| Description | Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. It is a mixture of the sodium salts of estrogen conjugates found in horses, such as estrone sulfate and equilin sulfate. CEEs are available in the form of both natural preparations manufactured from the urine of pregnant mares and fully synthetic replications of the natural preparations. They are formulated both alone and in combination with progestins such as medroxyprogesterone acetate. CEEs are usually taken by mouth, but can also be given by application to the skin or vagina as a cream or by injection into a blood vessel or muscle.
|
| Classification | Unknown |
| Drug class | estrogens |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 12126-59-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201649 |
| ChEBI ID | — |
| PubChem CID | 656613 |
| DrugBank | DB00286 |
| UNII ID | — |
Target
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Variants
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Financial
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Premarin – Pfizer
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Safety
Black-box Warning
Black-box warning for: Duavee, Premarin, Premphase, Premphase prempro, Prempro
Adverse Events
0 adverse events reported
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