Estrogens conjugated
Amnestrogen, Duavee, Estratab, Evex, Femogen, Menest, Menrium, Milprem, Pmb, Premarin, Premphase, Prempro (estrogens, conjugated) is an unknown pharmaceutical. Estrogens, conjugated was first approved as Menrium 5-2 on 1982-01-01.
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Menopause | D008593 | EFO_0003922 | N95 | 6 | 4 | 4 | 7 | 2 | 23 |
| Postmenopause | D017698 | — | — | 8 | 5 | 3 | 2 | 3 | 21 |
| Atrophy | D001284 | — | — | 2 | — | 5 | 1 | 2 | 10 |
| Carcinoma | D002277 | — | C80.0 | 1 | 6 | 1 | 1 | — | 9 |
| Atrophic vaginitis | D059268 | EFO_1001271 | — | 2 | — | 3 | 3 | 1 | 9 |
| Vaginitis | D014627 | EFO_0005757 | N76 | 3 | — | 1 | 3 | 2 | 9 |
| Hot flashes | D019584 | — | — | — | — | 4 | 2 | 2 | 8 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | — | 1 | 4 | 1 | 6 |
| Prolapse | D011391 | — | — | — | — | 1 | 4 | 1 | 6 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | 2 | 2 | 1 | — | 5 |
Show 27 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 3 | 19 | 13 | — | 3 | 34 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 9 | 2 | — | 4 | 19 |
| Adenocarcinoma | D000230 | — | — | 1 | 8 | 2 | — | — | 11 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 1 | — | 6 | — | 2 | 9 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | 5 | — | — | 6 |
| Neoplasms | D009369 | — | C80 | — | 3 | 1 | — | — | 4 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 3 | — | — | 4 |
| Coronary disease | D003327 | — | — | — | 1 | 4 | — | — | 4 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | 4 | — | — | 4 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | 3 | — | — | 3 |
Show 10 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Triple negative breast neoplasms | D064726 | — | — | 1 | 4 | — | — | — | 4 |
| Male breast neoplasms | D018567 | — | — | — | 2 | — | — | 1 | 3 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 2 | — | — | — | 2 |
| Lymphatic metastasis | D008207 | EFO_1001364 | — | — | 1 | — | — | — | 1 |
| Risk reduction behavior | D040242 | — | — | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 1 | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
| Carcinoma in situ | D002278 | — | D09.9 | — | 1 | — | — | — | 1 |
| Breast carcinoma in situ | D000071960 | — | D05 | — | 1 | — | — | — | 1 |
Show 22 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | — | — | — | 1 | 2 |
| Estrogen replacement therapy | D015914 | — | — | 2 | — | — | — | — | 2 |
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | 1 | — | — | — | 1 | 2 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | — | 1 |
| Sleep | D012890 | GO_0030431 | — | 1 | — | — | — | — | 1 |
| Metrorrhagia | D008796 | — | N92.1 | 1 | — | — | — | — | 1 |
| Premature menopause | D008594 | — | E28.31 | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
Show 2 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
| Gender dysphoria | D000068116 | — | F64 | — | — | — | — | 1 | 1 |
| Breast density | D000071060 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Estrogens conjugated |
| INN | — |
| Description | Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. It is a mixture of the sodium salts of estrogen conjugates found in horses, such as estrone sulfate and equilin sulfate. CEEs are available in the form of both natural preparations manufactured from the urine of pregnant mares and fully synthetic replications of the natural preparations. They are formulated both alone and in combination with progestins such as medroxyprogesterone acetate. CEEs are usually taken by mouth, but can also be given by application to the skin or vagina as a cream or by injection into a blood vessel or muscle.
|
| Classification | Unknown |
| Drug class | estrogens |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 12126-59-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201649 |
| ChEBI ID | — |
| PubChem CID | 656613 |
| DrugBank | DB00286 |
| UNII ID | — |
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Premarin – Pfizer
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0 adverse events reported
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