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Drug ReportsOestrogens conjugated
Estrogens conjugated
Duavee, Menest, Menrium, Milprem, Pmb, Premarin, Premphase, Prempro (estrogens, conjugated) is an unknown pharmaceutical. Estrogens, conjugated was first approved as Menrium 5-2 on 1982-01-01.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Premarin (generic drugs available since 1982-01-01, discontinued: Amnestrogen, Estratab, Evex, Femogen)
Combinations
Duavee, Premphase, Prempro (discontinued: Menrium, Milprem, Pmb, Premphase (premarin;cycrin ), Prempro (premarin;cycrin))
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bazedoxifene acetate
+
Estrogens
+
conjugated
Tradename
Company
Number
Date
Products
DUAVEEWYETH PHARMSN-022247 RX2013-10-03
1 products, RLD, RS
Chlordiazepoxide
+
Estrogens
+
esterified
Tradename
Company
Number
Date
Products
MENRIUM 5-2RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 5-4RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 10-4RocheN-014740 DISCN1982-01-01
1 products
Hide discontinued
Estrogens
+
conjugated
Tradename
Company
Number
Date
Products
PREMARINWYETH PHARMSN-004782 RX1982-01-01
5 products, RLD, RS
PREMARINWYETH PHARMSN-010402 RX1982-01-01
1 products, RLD, RS
PREMARINWYETH PHARMSN-020216 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Estrogens
+
conjugated
+
Medroxyprogesterone acetate
Tradename
Company
Number
Date
Products
PREMPROWYETH PHARMSN-020527 RX1995-11-17
4 products, RLD, RS
PREMPHASE 14/14WYETH PHARMSN-020527 RX1995-11-17
1 products, RLD, RS
Show 2 discontinued
Estrogens
+
conjugated
+
Meprobamate
Tradename
Company
Number
Date
Products
MILPREM-400Medpointe Pharm HlcN-011045 DISCN1982-01-01
1 products
MILPREM-200Medpointe Pharm HlcN-011045 DISCN1982-01-01
1 products
PMB 400WyethN-010971 DISCN1982-01-01
1 products
PMB 200WyethN-010971 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
cenestinNew Drug Application2004-09-01
duaveeNew Drug Application2023-11-01
enjuviaNew Drug Application2010-03-01
menestANDA2019-09-19
premarinNew Drug Application2023-12-03
premphaseANDA2012-11-26
premphase premproNew Drug Application2023-11-29
premproNew Drug Application2020-05-28
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Bazedoxifene Acetate / Estrogens, Conjugated, Duavee, Wyeth Pharms
76830512027-03-10DS, DPU-594, U-904
64795352024-05-06DPU-594, U-904
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3444 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50219614276412081263
InfertilityD007246HP_0000789—1118304654148
MenopauseD008593EFO_0003922N951720202633112
Healthy volunteers/patients———7885413103
Polycystic ovary syndromeD011085EFO_0000660E28.241017274094
NeoplasmsD009369—C804336411182
ContraceptionD003267——101224181476
Triple negative breast neoplasmsD064726——274961271
OsteoporosisD010024HP_0000939M81.061220111664
PostmenopauseD017698——10111451654
Show 143 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471—C6183313—856
Endometrial neoplasmsD016889EFO_0004230—7356—648
Ovarian neoplasmsD010051EFO_0003893C5611246—238
Coronary diseaseD003327———211—517
Ductal carcinoma breastD018270——574—316
AdenocarcinomaD000230——3112—115
ArthralgiaD018771HP_0002829M25.5—32—1015
Fallopian tube neoplasmsD005185——174——12
Premature birthD047928EFO_0003917O60127—412
PainD010146EFO_0003843R52263—311
Show 77 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289——118——116
Thrombocytopenic purpura idiopathicD016553EFO_0007160D69.318———8
Type 2 diabetes mellitusD003924EFO_0001360E1144——18
Brain neoplasmsD001932EFO_0003833C7144———7
Central nervous system neoplasmsD016543——16———6
Endometrioid carcinomaD018269——23———5
Pulmonary arterial hypertensionD000081029———5———5
Pancreatic neoplasmsD010190EFO_0003860C2512——14
Colorectal neoplasmsD015179——44———4
Small cell lung carcinomaD055752——42———4
Show 143 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Therapeutic equivalencyD013810——11———112
Drug interactionsD004347——4———26
Type 1 diabetes mellitusD003922EFO_0001359E101———23
Kallmann syndromeD017436Orphanet_478E23.01———23
HyperinsulinismD006946HP_0000842E16.11———23
Hepatitis cD006526—B19.23————3
LeukemiaD007938—C951———12
Chronic hepatitis cD019698EFO_0004220B18.22————2
Drug-related side effects and adverse reactionsD064420—T88.71———12
SleepD012890GO_0030431—1————1
Show 22 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Menstrual cycleD008597——————44
Blood pressureD001794EFO_0004325—————33
Premature menopauseD008594HP_0008209E28.31————33
Vascular stiffnessD059289——————33
HeadacheD006261HP_0002315R51————33
Mood disordersD019964EFO_0004247F30-F39————33
Gender identityD005783——————33
Pregnancy rateD018873——————22
Feeding behaviorD005247——————22
Glucose metabolism disordersD044882——————22
Show 104 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEstrogens conjugated
INN—
Description
Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. It is a mixture of the sodium salts of estrogen conjugates found in horses, such as estrone sulfate and equilin sulfate. CEEs are available in the form of both natural preparations manufactured from the urine of pregnant mares and fully synthetic replications of the natural preparations. They are formulated both alone and in combination with progestins such as medroxyprogesterone acetate. CEEs are usually taken by mouth, but can also be given by application to the skin or vagina as a cream or by injection into a blood vessel or muscle.
Classification
Unknown
Drug classestrogens
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID12126-59-9
RxCUI—
ChEMBL IDCHEMBL1201649
ChEBI ID—
PubChem CID656613
DrugBankDB00286
UNII ID—
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Premarin – Pfizer
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 69,627 documents
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Safety
Black-box Warning
Black-box warning for: Duavee, Menest, Premarin, Premphase, Premphase prempro, Prempro
Adverse Events
Top Adverse Reactions
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56,271 adverse events reported
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